盐酸二甲双胍

盐酸二甲双胍

别名：1,1-二甲基双胍盐酸盐

CAS号：1115-70-4

分子式：C₄H₁₁N₅.HCl

分子量：165.62

EINECS: 214-230-6

含量：≥98.5%

性状：白色结晶性粉末

包装：25Kg/纸板桶

作用：盐酸二甲双胍是一种双胍类口服降糖药，又称盐酸甲福明、格华止、美迪康，降糖作用比苯乙双胍要弱，主要作用是减少A细胞胰高血糖素的分泌，促进葡萄糖转化为糖原，具有不刺激胰岛β-细胞分泌胰岛素的特性。

降糖的作用机制如下：

1.增加周围组织对胰岛素的敏感性,增加胰岛素介导的葡萄糖利用.

2.增加非胰岛素依赖的组织对葡萄糖的利用,如脑、血细胞、肾髓质、肠道、皮肤等。

3.抑制肝糖原异生作用，降低肝糖输出。

4.抑制肠壁细胞摄取葡萄糖。

5.抑制胆固醇的生物合成和贮存，降低血甘油三酯、总胆固醇水平。

临床上盐酸二甲双胍主要用于治疗单纯饮食控制不满意的Ⅱ型糖尿病患者，尤其是肥胖和伴高胰岛素血症者，用本药不但有降血糖作用，还可能有减轻体重和高胰岛素血症的效果。对某些磺酰脲类疗效差的患者可奏效，如与磺酰脲类、小肠糖苷酶抑制剂或噻唑烷二酮类降糖药合用，较分别单用的效果更好。亦可用于胰岛素治疗的患者，以减少胰岛素用量。

 

 

Metformin hydrochloride

​​Synonyms：1,1-Dimethylbiguanide hydrochloride

CAS: 1115-70-4

MF: C₄H₁₁N₅.HCl

MW: 165.62

EINECS: 214-230-6

Assay: ≥98.5%

Chemical Properties：White crystalline powder

Package：25Kg/Cardboard drum

Usage：Metformin hydrochloride is a biguanide oral hypoglycemic agents, also known as metformin hydrochloride glucophage, Medicom hypoglycemic effect than phenformin weaker, the main role is to reduce the A cell glucagon secretion,to promote the conversion of glucose to glycogen, has the characteristics of not stimulate islet β-cells secrete insulin.
The hypoglycemic effect mechanism is as follows:

1.Increased the surrounding tissue sensitivity to insulin, increased insulin-mediated glucose utilization.

2.Increase the organization of non-insulin-dependent glucose utilization, such as brain, blood cells, renal medulla, intestinal, skin.

3. Inhibition of hepatic gluconeogenesis role in reducing hepatic glucose output.

4. Inhibit intestinal wall cellular uptake of glucose.

5. Inhibition of cholesterol biosynthesis and storage, reduce blood triglycerides, total cholesterol levels.

    Clinical metformin hydrochloride for the treatment of the dissatisfied simple diet control in patients with type II diabetes, obesity and associated with hyperinsulinemia hypoglycemic effect, not only with the drug, may also lose weight and high insulin hyperlipidemiaeffect. Some sulfonylurea efficacy in patients with poor work, such as intestinal glucosidase inhibitors or thiazolidinediones ketones hypoglycemic agents in combination with sulfonylurea, better than were alone. Can also be used in patients 變頻馬達